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Genetics links endometriosis and IBS

Date:
October 26, 2023
Source:
University of Queensland
Summary:
Researchers have found a significant relationship between the risks for endometriosis and common gastrointestinal disorders such as IBS, peptic ulcer disease (PUD) and gastro-oesophageal reflux disease (GORD). Sufferers can find it difficult to distinguish the source of their pain leading to confusion or misdiagnosis and years of delay in treatment during which time the endometriosis can progress to more severe disease -- endometriosis should be considered as a possible cause if a woman presents to her GP with abdominal pain and gastrointestinal symptoms.
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University of Queensland researchers have shown that endometriosis and irritable bowel syndrome (IBS) share genetic risk factors, explaining why patients with one condition may also have the other.

Professor Grant Montgomery and Dr Sally Mortlock at UQ's Institute for Molecular Bioscience found a significant relationship between the risks for endometriosis and common gastrointestinal disorders such as IBS, peptic ulcer disease (PUD) and gastro-oesophageal reflux disease (GORD).

"This genetic finding supports the clinical observation of an increased incidence of gastrointestinal disorders in women with endometriosis," Professor Montgomery said.

"We hope that this study will raise more awareness about the overlap of these conditions."

Endometriosis is a severe condition affecting 1 in 7 women caused by tissue that resembles the uterus lining growing outside the uterus.

Women with endometriosis are twice as likely to have an IBS diagnosis compared to women without the disease and 1.4 times more likely to have a diagnosis of GORD.

"Sufferers can find it difficult to distinguish the source of their pain leading to confusion or misdiagnosis and years of delay in treatment during which time the endometriosis can progress to more severe disease," Professor Montgomery said.

"Endometriosis should be considered as a possible cause if a woman presents to her GP with abdominal pain and gastrointestinal symptoms.

"As our knowledge of risk factors for endometriosis increases, we hope to move closer to understanding how the disease develops and improve treatments and diagnosis," he said.

Professor Montgomery and Dr Mortlock worked with Dr Fei Yang from IMB and colleagues at UQ's School of Public Health on the genetic studies.


Story Source:

Materials provided by University of Queensland. Note: Content may be edited for style and length.


Journal Reference:

  1. Fei Yang, Yeda Wu, Richard Hockey, Jenny Doust, Gita D. Mishra, Grant W. Montgomery, Sally Mortlock. Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management. Cell Reports Medicine, 2023; 101250 DOI: 10.1016/j.xcrm.2023.101250

Cite This Page:

University of Queensland. "Genetics links endometriosis and IBS." ScienceDaily. ScienceDaily, 26 October 2023. <www.sciencedaily.com/releases/2023/10/231026161103.htm>.
University of Queensland. (2023, October 26). Genetics links endometriosis and IBS. ScienceDaily. Retrieved October 31, 2024 from www.sciencedaily.com/releases/2023/10/231026161103.htm
University of Queensland. "Genetics links endometriosis and IBS." ScienceDaily. www.sciencedaily.com/releases/2023/10/231026161103.htm (accessed October 31, 2024).

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